intestinal cells

[Nature] Investigators showed that Apc-mutant intestinal stem cells (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.

[iScience] Scientists reported that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analogue, Nortopsentin 234, led to an initial reduction of proliferative and clonogenic potential of colorectal cancer sphere cells (CR-CSphCs), followed by an adaptive response selecting the CR-CSphCs resistant compartment.

[Stem Cell Research & Therapy] Cecal ligation and puncture-induced sepsis rats and lipopolysaccharide-stimulated intestinal epithelial cells to investigate the effect of mesenchymal stem cell-derived microvesicles on intestinal barrier dysfunction.

[Cell Host & Microbe] In the intestine, Salmonella enterica serovar Typhimurium actively invaded intestinal epithelial cells and survived in the Salmonella-containing vacuole and the cell cytosol.

[Proceedings of the National Academy of Sciences of the United States of America] Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.

[STAR Protocols] Investigators provided a detailed protocol for an autologous in vitro long-term 3D co-culture system of human intestinal CD4+ T cells and intestinal stem cells to study T cell-intestinal epithelial cell interactions during tissue development and inflammation.