High Yap and Mll1 Promote a Persistent Regenerative Cell State Induced by Notch Signaling and Loss of p53

By
Justin.choi
-
0
27
Using intestinal organoids, researchers showed that concomitant activation of Notch signaling and ablation of p53 induce a highly proliferative and regenerative cell state, which was associated with increased levels of Yap and the histone methyltransferase Mll1.
[Proceedings of the National Academy of Sciences of the United States of America]
Heuberger, J., Grinat, J., Kosel, F., Liu, L., Kunz, S., Vidal, R. O., Keil, M., Haybaeck, J., Robine, S., Louvard, D., Regenbrecht, C., Sporbert, A., Sauer, S., Eyss, B. von, Sigal, M., & Birchmeier, W. (2021). High Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53. Proceedings of the National Academy of Sciences, 118(22). https://doi.org/10.1073/pnas.2019699118 Cite
Abstract