intestinal cells

[Acta Biomaterialia] The authors discuss the status, applications, challenges and perspectives of intestinal organoid systems emphasising on hydrogels and their properties suitable for intestinal organoid culture.

[Cell] Scientists illuminated cell states, transcription factors, and organ-specific epithelial stem cell and mesenchyme interactions across lineages.

[mBio] Scientists used a human intestinal organoid model to define host transcriptional responses to S. Typhimurium infection, also determining host pathways dependent on Salmonella pathogenicity island- 1- and -2-encoded type 3 secretion systems

[Stem Cell Research & Therapy] Intestinal organoids derived from mouse small intestine were treated with vitamin D3, and the effects on intestinal stemness and differentiation were evaluated using real-time PCR and immunofluorescence staining of the distinct lineage markers.

[Scientific Reports] Investigators found that the histone acetyltransferases inhibitor C646 augmented anti-tumor effects in vitro by inhibiting cell proliferation and cell cycle progression concomitantly with suppression of acetylated H3K9 and H3K27 expression.

[Cellular and Molecular Gastroenterology and Hepatology] The authors determined the role of LPA receptor 5 (LPA5) in regulation of intestinal epithelial barrier. Human colonic epithelial cell lines were used to determine the LPA5-mediated signaling pathways that regulate epithelial barrier.