intestinal cells

[Nature Cell Biology] Researchers uncovered a previously unrecognized crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration.

[Nature Cell Biology] The authors showed that the adult intestinal tracheae are dynamic and respond to enteric infection, oxidative agents and tumors with increased terminal branching.

[Scientific Reports] Using a novel screening method, investigators identified novel transcription factors that regulated the intestinal stem cell fate upon endoplasmic reticulum stress.

[Scandinavian Journal of Gastroenterology] The authors found that LINGO3 was broadly expressed on human enterocytes and sparsely on discrete cells within the crypt niche, that contained sintestinal stem cells.

[Science Immunology] The authors reported that after distinct types of intestinal epithelial damage, IL-1R1 signaling in GREM1+ mesenchymal cells increased production of R-spondin 3, a Wnt agonist required for intestinal stem cell self-renewal.

[EMBO Journal] Investigators showed that the YAP‐TEAD transcription factor is a key downstream effector of Wnt signaling in the intestine.