Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsInvestigators showed that the YAP‐TEAD transcription factor is a key downstream effector of Wnt signaling in the intestine.
[EMBO Journal]
6445218 {6445218:N5X9X55D} apa 50 1 161979 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-36ebbea06789cd706c33592dafa21836%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22N5X9X55D%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Guillermin%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-05%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGuillermin%2C%20O.%2C%20Angelis%2C%20N.%2C%20Sidor%2C%20C.%20M.%2C%20Ridgway%2C%20R.%2C%20Baulies%2C%20A.%2C%20Kucharska%2C%20A.%2C%20Antas%2C%20P.%2C%20Rose%2C%20M.%20R.%2C%20Cordero%2C%20J.%2C%20Sansom%2C%20O.%2C%20Li%2C%20V.%20S.%20W.%2C%20%26amp%3B%20Thompson%2C%20B.%20J.%20%282021%29.%20Wnt%20and%20Src%20signals%20converge%20on%20YAP-TEAD%20to%20drive%20intestinal%20regeneration.%20%3Ci%3EThe%20EMBO%20Journal%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29%2C%20e105770.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.15252%5C%2Fembj.2020105770%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.15252%5C%2Fembj.2020105770%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DN5X9X55D%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Wnt%20and%20Src%20signals%20converge%20on%20YAP-TEAD%20to%20drive%20intestinal%20regeneration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oriane%22%2C%22lastName%22%3A%22Guillermin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikolaos%22%2C%22lastName%22%3A%22Angelis%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Clara%20M%22%2C%22lastName%22%3A%22Sidor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rachel%22%2C%22lastName%22%3A%22Ridgway%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Baulies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Kucharska%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pedro%22%2C%22lastName%22%3A%22Antas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Melissa%20R%22%2C%22lastName%22%3A%22Rose%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Cordero%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Owen%22%2C%22lastName%22%3A%22Sansom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vivian%20S%20W%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Barry%20J%22%2C%22lastName%22%3A%22Thompson%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%20Wnt%20signalling%20induces%20a%20gradient%20of%20stem%5C%2Fprogenitor%20cell%20proliferation%20along%20the%20crypt-villus%20axis%20of%20the%20intestine%2C%20which%20becomes%20expanded%20during%20intestinal%20regeneration%20or%20tumour%20formation.%20The%20YAP%20transcriptional%20co-activator%20is%20known%20to%20be%20required%20for%20intestinal%20regeneration%2C%20but%20its%20mode%20of%20regulation%20remains%20controversial.%20Here%20we%20show%20that%20the%20YAP-TEAD%20transcription%20factor%20is%20a%20key%20downstream%20effector%20of%20Wnt%20signalling%20in%20the%20intestine.%20Loss%20of%20YAP%20activity%20by%20Yap%5C%2FTaz%20conditional%20knockout%20results%20in%20sensitivity%20of%20crypt%20stem%20cells%20to%20apoptosis%20and%20reduced%20cell%20proliferation%20during%20regeneration.%20Gain%20of%20YAP%20activity%20by%20Lats1%5C%2F2%20conditional%20knockout%20is%20sufficient%20to%20drive%20a%20crypt%20hyperproliferation%20response.%20In%20particular%2C%20Wnt%20signalling%20acts%20transcriptionally%20to%20induce%20YAP%20and%20TEAD1%5C%2F2%5C%2F4%20expression.%20YAP%20normally%20localises%20to%20the%20nucleus%20only%20in%20crypt%20base%20stem%20cells%2C%20but%20becomes%20nuclear%20in%20most%20intestinal%20epithelial%20cells%20during%20intestinal%20regeneration%20after%20irradiation%2C%20or%20during%20organoid%20growth%2C%20in%20a%20Src%20family%20kinase-dependent%20manner.%20YAP-driven%20crypt%20expansion%20during%20regeneration%20involves%20an%20elongation%20and%20flattening%20of%20the%20Wnt%20signalling%20gradient.%20Thus%2C%20Wnt%20and%20Src-YAP%20signals%20cooperate%20to%20drive%20intestinal%20regeneration.%22%2C%22date%22%3A%22May%205%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.15252%5C%2Fembj.2020105770%22%2C%22ISSN%22%3A%220261-4189%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.embopress.org%5C%2Fdoi%5C%2Ffull%5C%2F10.15252%5C%2Fembj.2020105770%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-07T00%3A19%3A52Z%22%7D%7D%5D%7D
Guillermin, O., Angelis, N., Sidor, C. M., Ridgway, R., Baulies, A., Kucharska, A., Antas, P., Rose, M. R., Cordero, J., Sansom, O., Li, V. S. W., & Thompson, B. J. (2021). Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration. The EMBO Journal, n/a(n/a), e105770. https://doi.org/10.15252/embj.2020105770 Cite
