LINGO3 Regulates Mucosal Tissue Regeneration and Promotes TFF2 Dependent Recovery from Colitis

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The authors found that LINGO3 was broadly expressed on human enterocytes and sparsely on discrete cells within the crypt niche, that contained sintestinal stem cells.
[Scandinavian Journal of Gastroenterology]
Zullo, K. M., Douglas, B., Maloney, N. M., Ji, Y., Wei, Y., Herbine, K., Cohen, R., Pastore, C., Cramer, Z., Wang, X., Wei, W., Somsouk, M., Hung, L. Y., Lengner, C., Kohanski, M. H., Cohen, N. A., & Herbert, D. R. (2021). LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Scandinavian Journal of Gastroenterology, 0(0), 1–15. https://doi.org/10.1080/00365521.2021.1917650 Cite
Abstract