intestinal cells

[Current Biology] Through a series of studies spanning in vitro efferocytosis, ex vivo intestinal organoids, and in vivo Cre-mediated deletion of Paneth cells, researchers showed that Paneth cells mediate apoptotic cell uptake of dying neighbors.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that untransformed intestinal epithelial cell layers initiate immediate focal contractions, affecting hundreds to thousands of epithelial cells, in response to bacterial infection.

[Genes & Immunity] The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.

[Nature Metabolism] Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.

[Molecules] Scientists studied the role of exopolysaccharides produced by lactic acid bacteria identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells.

[Life Sciences] The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.