intestinal stem cells

[Proceedings of the National Academy of Sciences of the United States of America] Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.

[Worldwide Cancer Research (EurekAlert!)] Following successful research that showed how a drug available on the NHS could boost fitness of healthy stem cells in the gut, a clinical trial funded by the Dutch Cancer Society testing the effect of lithium of bowel cancer development in individuals with familial adenomatous polyposis will be performed in the Netherlands.

[Nature] Investigators showed that Apc-mutant intestinal stem cells (ISCs) functioned as bona fide supercompetitors by secreting WNT antagonists, thereby inducing differentiation of neighbouring wild-type ISCs.

[STAR Protocols] Investigators provided a detailed protocol for an autologous in vitro long-term 3D co-culture system of human intestinal CD4+ T cells and intestinal stem cells to study T cell-intestinal epithelial cell interactions during tissue development and inflammation.

[Cell] Scientists illuminated cell states, transcription factors, and organ-specific epithelial stem cell and mesenchyme interactions across lineages.

[Nature Cell Biology] Researchers uncovered a previously unrecognized crosstalk between adult intestinal stem cells in Drosophila and the vasculature-like tracheal system, which is essential for intestinal regeneration.