ischemic stroke

[Scientific Reports] Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.

[Acta Pharmacologica Sinica] Scientists describe how Treg cells fluctuate and play a role in the regulation of immune responses after ischemic stroke in both experimental animals and humans, and summarize their biological functions and mechanisms in both CNS and periphery.

[ACS Nano] Researchers determined the therapeutic function of embryonic stem cell derived extracellular vesicles, specifically focusing on their role in immunomodulation after ischemic stroke.

[Translational Stroke Research] In a transient middle cerebral artery occlusion rat model and an oxygen and glucose deprivation and reoxygenation induced astrocytic injury model, the authors showed that receptor-interacting protein 1 (RIP1) kinase was significantly elevated in the reactive astrocytes.

[Signal Transduction and Targeted Therapy] Scientists showed that intravenously administered MSCs preferentially migrate to the marginal zone (MZ) of the spleen, preserving injured MZ B cells and ameliorating post-stroke infection and mortality in the mouse middle cerebral artery occlusion model of acute ischemic stroke.

[Scientific Reports] In Sprague–Dawley rats, hindlimb ischemia was generated by femoral artery removal, then seven days after ischemic induction 1 × 105 SB623 cells or PBS was injected into the ischemic adductor muscle.