islets

[eLife] Researchers utilized mouse islets to determine how microtubules affect secretion toward the vascular extracellular matrix at single cell and subcellular levels.

[Diabetes] Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.

[Frontiers in Endocrinology] The authors differentiated iPSC from one donor into dendritic cells, macrophages, endothelial cells, and β-cells, and engineered T cell avatars from the same donor to provide an in vitro platform to study genetic influences on critical cellular interactions.

[Translational Research] Researchers demonstrated a direct effect of cholecystokinin to reduce cytokine-mediated apoptosis in a β-cell line and in isolated mouse islets in a receptor-dependent manner.

[Biochimie] Semaglutide increased islet cell proliferation and recovered islet size and alpha- and beta-cell masses.

[Cancer Cell] Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.