islets

[PLoS One] A new “endocrine pancreas” delivered islet hormones physiologically into the hepatic portal vein. Treatment of insulin-dependent dogs with allogeneic canine Neo-Islets consistently improved glycemic control without the need for antirejection drugs.

[Cell Reports] Investigators analyzed over two million cells from 16 pancreata obtained from donors with type 2 diabetes and 13 pancreata from age-similar non-diabetic controls.

[SymbioCellTech (GlobeNewswire, Inc.)] SymbioCellTech announced the publication of a paper demonstrating the potency and efficacy of its innovative and proprietary human Neo-Islet™ in a third, clinically relevant model of human Type 1 Diabetes.

[Diabetologia] Researchers profiled CD4+ regulatory T cells in a small but well-characterized cohort of extreme slow progressors with a median age 43, followed up for 18–32 years.

[Scientific Reports] Investigators elucidated whether regulation of growth hormone secretagogue receptor-1a (GHS-R1a), one of the ghrelin receptors, improved the therapeutic effects of islet transplantation using [D-Lys3]-GHRP-6, a specific GHS-R1a antagonist.

[Islets] Aiming to contribute to a better understanding of the relationship between structural and functional properties of pancreatic islets, researchers reconstructed human and mice islets in order to perform a structural comparison based on both morphologic and network-derived metrics.