Intraperitoneal Administration of Human “Neo-Islets”, 3-D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells, Normalizes Blood Glucose Levels in Streptozotocin-Diabetic NOD/SCID Mice: Significance for Clinical Trials

A new “endocrine pancreas” delivered islet hormones physiologically into the hepatic portal vein. Treatment of insulin-dependent dogs with allogeneic canine Neo-Islets consistently improved glycemic control without the need for antirejection drugs.