islets

[Scientific Reports] Scientists found that islets from pregnant Prlr+/− mice are more vulnerable to glucolipotoxicity-induced apoptosis than islets from pregnant βPrlR+/− mice.

[Scientific Reports] Researchers demonstrated that equilibration of mouse islets with small molecules in aqueous solutions could be accelerated from greater than 24 to 6 h by increasing incubation temperature to 37 °C.

[Journal of Molecular Endocrinology] Scientists used rat primary islet cells and MIN6 mouse beta cell line to investigate TNF-related apoptosis-inducing ligand (TRAIL)-induced proliferation.

[Scientific Reports] To isolate β cell precursors from late stage pancreatic endocrine progenitor (EP) cells derived from iPS cells, researchers have identified CD82, a member of the tetraspanin family. CD82+ cells at the EP stage differentiated into endocrine cells more efficiently than CD82− EP stage cells.

[Journal of Neuroendocrinology] Scientists examined the expression of other Family B Gs‐protein coupled receptor in the cell line and assessed cAMP elevation and neuritogenesis after treatment with their cognate peptide ligands.

[Nature Communications] The CRL neddylation inhibitor Pevonedistat/MLN4924 stabilizes ETV5 and remediates the hyperinsulinemia and obesity/diabetes phenotypes of these mice.