Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsScientists used rat primary islet cells and MIN6 mouse beta cell line to investigate TNF-related apoptosis-inducing ligand (TRAIL)-induced proliferation.
[Journal of Molecular Endocrinology]
7753456 {7753456:8KWZK6TB} apa 50 1 162353 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-9bbd51b03e437d36999b6d084d597afd%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%228KWZK6TB%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kahraman%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EKahraman%2C%20S.%2C%20Yilmaz%2C%20O.%2C%20Altunbas%2C%20H.%20A.%2C%20Dirice%2C%20E.%2C%20%26amp%3B%20Sanlioglu%2C%20A.%20D.%20%282021%29.%20TRAIL%20induces%20proliferation%20in%20rodent%20pancreatic%20beta%20cells%20via%20AKT%20activation.%20%3Ci%3EJournal%20of%20Molecular%20Endocrinology%3C%5C%2Fi%3E%2C%20%3Ci%3E66%3C%5C%2Fi%3E%284%29%2C%20325%26%23x2013%3B338.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1530%5C%2FJME-20-0037%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1530%5C%2FJME-20-0037%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3D8KWZK6TB%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22TRAIL%20induces%20proliferation%20in%20rodent%20pancreatic%20beta%20cells%20via%20AKT%20activation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sevim%22%2C%22lastName%22%3A%22Kahraman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ozlem%22%2C%22lastName%22%3A%22Yilmaz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hasan%20Ali%22%2C%22lastName%22%3A%22Altunbas%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ercument%22%2C%22lastName%22%3A%22Dirice%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ahter%20Dilsad%22%2C%22lastName%22%3A%22Sanlioglu%22%7D%5D%2C%22abstractNote%22%3A%22%3Csection%20class%3D%5C%22abstract%5C%22%3E%3Cp%3EStrategies%20to%20increase%20functional%20pancreatic%20beta%20cell%20mass%20is%20of%20great%20interest%20in%20diabetes-related%20research.%20TNF-related%20apoptosis-inducing%20ligand%20%28TRAIL%29%20is%20well%20known%20to%20promote%20proliferation%20and%20survival%20in%20various%20cell%20types%2C%20including%20vascular%20smooth%20muscle%20and%20endothelial%20cells.%20Correlation%20between%20the%20protective%20nature%20of%20TRAIL%20on%20these%20cells%20and%20its%20proliferative%20effect%20is%20noteworthy.%20TRAIL%5Cu2019s%20seemingly%20protective%5C%2Ftherapeutic%20effect%20in%20diabetes%20prompted%20us%20to%20question%20whether%20it%20may%20act%20as%20an%20inducer%20of%20proliferation%20in%20pancreatic%20beta%20cells.%20We%20used%20rat%20primary%20islet%20cells%20and%20MIN6%20mouse%20beta%20cell%20line%20to%20investigate%20TRAIL-induced%20proliferation.%20Cell%20viability%20and%5C%2For%20death%20was%20analyzed%20by%20MTT%2C%20WST-1%2C%20and%20Annexin-V%5C%2FPI%20assays%2C%20while%20proliferation%20rates%20and%20pathways%20were%20assessed%20via%20immunocytochemical%20and%20Western%20blot%20analyses.%20Receptor%20neutralization%20antibodies%20identified%20the%20mediator%20receptors.%20Recombinant%20soluble%20TRAIL%20%28sTRAIL%29%20treatment%20led%20to%201.6-fold%20increased%20proliferation%20in%20insulin-positive%20cells%20in%20dispersed%20rat%20islets%20compared%20to%20the%20untreated%20group%2C%20while%20adenovirus-mediated%20overexpression%20of%20TRAIL%20increased%20the%20number%20of%20proliferating%20beta%20cells%20up%20to%20more%20than%20six-fold.%20sTRAIL%20or%20adenoviral%20vector-mediated%20TRAIL%20overexpression%20induced%20proliferation%20in%20MIN6%20cells%20also.%20TRAIL%5Cu2019s%20proliferative%20effect%20was%20mediated%20via%20AKT%20activation%2C%20which%20was%20suppressed%20upon%20specific%20inhibition.%20Neutralization%20of%20each%20TRAIL%20receptor%20reversed%20the%20proliferative%20effect%20to%20some%20degree%2C%20with%20the%20highest%20level%20of%20inhibition%20in%20death%20receptor%205%20%28DR5%29%20blockage%20in%20MIN6%20cells%20and%20in%20decoy%20receptor%201%20%28DcR1%29%20blockage%20in%20primary%20rat%20beta%20cells.%20Thus%2C%20TRAIL%20induces%20proliferation%20in%20rodent%20pancreatic%20beta%20cells%20through%20activation%20of%20the%20AKT%20pathway.%3C%5C%2Fp%3E%3C%5C%2Fsection%3E%22%2C%22date%22%3A%222021%5C%2F04%5C%2F01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1530%5C%2FJME-20-0037%22%2C%22ISSN%22%3A%221479-6813%2C%200952-5041%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjme.bioscientifica.com%5C%2Fview%5C%2Fjournals%5C%2Fjme%5C%2F66%5C%2F4%5C%2FJME-20-0037.xml%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%223XSKJF5U%22%5D%2C%22dateModified%22%3A%222021-05-18T19%3A05%3A37Z%22%7D%7D%5D%7D
Kahraman, S., Yilmaz, O., Altunbas, H. A., Dirice, E., & Sanlioglu, A. D. (2021). TRAIL induces proliferation in rodent pancreatic beta cells via AKT activation. Journal of Molecular Endocrinology, 66(4), 325–338. https://doi.org/10.1530/JME-20-0037 Cite
