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keratinocytes

High Proliferation and Delamination during Skin Epidermal Stratification

[Nature Communications] Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.

Keratinocyte-Derived Microvesicle Particles Mediate Ultraviolet B Radiation–Induced Systemic Immunosuppression

[Journal of Clinical Investigation] Researchers used both pharmacologic and genetic approaches in cells and mice to show that both the platelet-activating factor receptor and enzyme acid sphingomyelinase were necessary for UVB-MVP generation.

Ultraviolet Radiation Protection Potentials of Methylene Blue for Human Skin and Coral Reef Health

[Scientific Reports] Investigators tested the effects of Methylene blue on UVB ray-induced DNA double-strand breaks in primary human keratinocytes.

Differentiation-Related Zinc Finger Protein 750 Suppresses Cell Growth in Esophageal Squamous Cell Carcinoma

[Oncology Letters] The authors demonstrated that chemical manipulation of esophageal keratinocyte differentiation in mouse normal esophageal epithelial organoids implicated the involvement of the mouse homologue of ZNF750, Zfp750, in keratinocyte differentiation in premalignant cells.

Clinically Relevant Aberrant Filip1l DNA Methylation Detected in a Murine Model of Cutaneous Squamous Cell Carcinoma

[Ebiomedicine] Scientists found increased average methylation in mouse cutaneous squamous cell carcinomas (cSCC) as well as in stem-cell like, but not keratinocyte-like, human cSCC.

The Endoribonuclease N4BP1 Prevents Psoriasis by Controlling Both Keratinocytes Proliferation and Neutrophil Infiltration

[Cell Death & Disease] Researchers found that the expression of NEDD4-binding protein 1 (N4BP1) in skin was highest among all 54 tested tissues, and its expression was further upregulated in psoriatic skin.

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