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keratinocytes

ΔNp63-Senataxin Circuit Controls Keratinocyte Differentiation by Promoting the Transcriptional Termination of Epidermal Genes

[Proceedings of the National Academy of Sciences of the United States of America] Investigators elucidated a mechanism whereby ΔNp63 efficiently sustained the expression of epidermal differentiation genes.

Development of Functional Hybrid Scaffolds for Wound Healing Applications

[iScience] Hybrid hydrogels composed of chitosan and hyaluronic acid and collagen were prepared by polyelectrolyte complex self-assembly.

Spatiotemporal Dynamics of PIEZO1 Localization Controls Keratinocyte Migration during Wound Healing

[Biophysical Journal] Investigators showed through molecular, cellular and organismal studies that the mechanically-activated ion channel PIEZO1 regulated keratinocyte migration and wound healing.

Autophagy and Skin Wound Healing

[Burns & Trauma] Understanding the relationship between autophagy and skin wound healing may provide novel strategies for the clinical treatment of wound healing.

Particulate Matter-Induced Hypomethylation of Alu and LINE1 in Normal Human Bronchial Epithelial Cells and Epidermal Keratinocytes

[Genes and Environment] Researchers quantitatively measured the methylation content of Alu and LINE1 in particulate matter-treated normal human bronchial epithelial cells and normal human epidermal keratinocytes by using whole-genome bisulfite sequencing and pyrosequencing.

Normality Sensing Licenses Local T Cells for Innate-Like Tissue Surveillance

[Nature Immunology] Interruption of T cell antigen receptors-mediated ‘normality sensing’ had no impact on γδ T cell numbers but altered their signature phenotype, while the epidermal barrier function was compromised.

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