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keratinocytes

Unravelling the Role of Surface Modification in the Dermocompatibility of Silver Nanoparticles In Vitro and In Vivo

[Chemosphere] The authors illustrated that varying coating material for silver nanoparticles stabilization resulted in differential toxicity against dermal microbes and HaCaT keratinocytes in vitro and affects dermal absorption through intact/compromised skin in vivo.

Congenital Deficiency Reveals Critical Role of ISG15 in Skin Homeostasis

[Journal of Clinical Investigation] Investigators described two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment and characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.

A Single Dose of Ultraviolet-A Induces Proteome Remodeling and Senescence in Primary Human Keratinocytes

[Scientific Reports] Proteomic analysis was conducted to derive the cellular responses induced by an environmentally relevant dose of Ultraviolet-A (UVA) in primary human keratinocytes. Scientists investigated the effects of UVA on non-transformed immortalized keratinocytes.

Peripheral Tolerance by Treg via Constraining OX40 Signal in Autoreactive T Cells against Desmoglein 3, a Target Antigen in Pemphigus

[Proceedings of the National Academy of Sciences of the United States of America] Scientists used desmoglein 3, a pemphigus antigen expressed in keratinocytes, to analyze peripheral tolerance under physiological antigen-expression conditions.

Effect of the Flavonoids Quercetin and Taxifolin on UVA-Induced Damage to Human Primary Skin Keratinocytes and Fibroblasts

[Photochemical & Photobiological Sciences] Investigators evaluated the potential of quercetin and its structurally related flavonoid taxifolin to reduce UVA-caused damage to human primary dermal fibroblasts and epidermal keratinocytes obtained from identical donors.

Studying the In Vivo Application of a Liquid Dermal Scaffold in Promoting Wound Healing in a Mouse Model

[Experimental Dermatology] The authors evaluated the in vitro and in vivo properties of a novel liquid dermal scaffold in a delayed murine full thickness wound model. They compared this scaffold with two commercially- available granular collagen-based products

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