leukemia cells

[Nature Communications] Investigators showed that the adipocyte secretome upregulated the surface expression of Galectin-9 on human B-acute lymphoblastic leukemia cells which promoted chemoresistance.

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.

[Scientific Reports] Investigators explored the presence of cell-surface associated glucose regulated proteins (GRP78) in pediatric B-ALL at diagnosis and investigated the correlation with bona fide markers of leukemia.

[Frontiers in Immunology] Investigators explored the impact of epigenetic modifiers and differentiation agents on leukemia cell lines of B cell origin, as well as normal B cells.

[Cell Death & Disease] Administration of human umbilical cord MSC exosomes promoted imatinib-induced cell apoptosis through miR-145a-5p/USP6.

[Cancer Discovery] The authors leveraged genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia exploited peripheral serotonin-signaling to remodel the endosteal niche to its advantage.