Tag results:
leukemia
Hematopoiesis News
Targeting CD38 in Acute Myeloid Leukemia Interferes with Leukemia Trafficking and Induces Phagocytosis
[Scientific Reports] In line with a predominantly microenvironment-mediated activity of daratumumab in acute myeloid leukemia (AML), CD38 inhibition significantly induced antibody-dependent phagocytosis and showed interference with AML cell trafficking in vivo in a xenograft transplantation model, but overall lacked robust anti-leukemic effects.
Hematopoiesis News
Acute Myeloid Leukemia Maturation Lineage Influences Residual Disease and Relapse Following Differentiation Therapy
[Nature Communications] Researchers indicated that relapse can originate from therapy-resistant mature acute myeloid leukemia cells, and suggested differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome.
Hematopoiesis News
Biosight Announces Initiation of Phase II Clinical Trial of Aspacytarabine for MDS and AML
[Biosight Ltd. (GlobeNewswire, Inc.)] Biosight Ltd.,announced the initiation of a Phase II trial to evaluate aspacytarabine, Biosight’s proprietary antimetabolite, as a second line treatment for patients with relapsed or refractory myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
Cancer Stem Cell News
Prognostic Significance of NT5E/CD73 in Neuroblastoma and Its Function in CSC Stemness Maintenance
[Cell Biology and Toxicology] Researchers investigated its expression profile in neuroblastoma (NB), its association with NB clinical outcomes, and its influence in the regulation of cancer stem cells’ (CSCs) stemness maintenance.
Cell Therapy News
CD33-Directed Immunotherapy with Third-Generation Chimeric Antigen Receptor T Cells and Gemtuzumab Ozogamicin in Intact and CD33-Edited Acute Myeloid Leukemia and Hematopoietic Stem and Progenitor...
[International Journal of Cancer] Investigators introduced a CD33-directed third-generation CAR T cell product for the treatment of patients with acute myeloid leukemia.
Cancer Stem Cell News
Therapeutic Inhibition of GAS6-AS1/YBX1/MYC Axis Suppresses Cell Propagation and Disease Progression of Acute Myeloid Leukemia
[Journal of Experimental & Clinical Cancer Research] Gain or loss of functional leukemia cell models were produced, and in vitro and in vivo experiments were applied to demonstrate its leukemogenic phenotypes.