Targeting CD38 in Acute Myeloid Leukemia Interferes with Leukemia Trafficking and Induces Phagocytosis

In line with a predominantly microenvironment-mediated activity of daratumumab in acute myeloid leukemia (AML), CD38 inhibition significantly induced antibody-dependent phagocytosis and showed interference with AML cell trafficking in vivo in a xenograft transplantation model, but overall lacked robust anti-leukemic effects.