leukemia

[Haematologica] Researchers used single-cell mass cytometry to study signal transduction pathways such as the JAK-STAT, PI3K-AKT-mTOR and MEK-ERK pathways in 16 diagnostic and 5 relapsed T cell acute lymphoblastic leukemia primary samples and investigated the in vitro response of cells to interleukin-7 and the inhibitor BEZ-235.

[International Immunology] To apply the iPSC-based cell therapy in an allogeneic setting, the authors developed a method in which non-T cell-derived iPSCs were transduced with exogenous T cell receptor genes.

[Molecular Medicine] TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.

[Cell Death Discovery] Researchers performed high-throughput screening and identified that oridonin, an ent-kaurene diterpenoid extracted from the Chinese herb Rabdosia rubescens, inhibited DNMT3A R882 mutant leukemic cells at a low-micromolar concentration.

[Cancer Cell International] The authors take a look at the latest advances in the use of chitosan in the treatment and improvement of leukemia.

[Blood] MB1-47 treatment in T cell acute lymphoblastic leukemia cells robustly inhibited cell proliferation via both cytostatic and cytotoxic effects as a result of compromised mitochondrial energy and metabolite depletion, which severely impaired nucleotide biosynthesis.