Either IL-7 Activation of JAK-STAT or BEZ Inhibition of PI3K-AKT-mTOR Pathways Dominates the Single-Cell Phosphosignature of Ex Vivo Treated Pediatric T Cell Acute Lymphoblastic Leukemia Cells

Researchers used single-cell mass cytometry to study signal transduction pathways such as the JAK-STAT, PI3K-AKT-mTOR and MEK-ERK pathways in 16 diagnostic and 5 relapsed T cell acute lymphoblastic leukemia primary samples and investigated the in vitro response of cells to interleukin-7 and the inhibitor BEZ-235.