leukemia

[Cell Death & Disease] Investigators established an acquired glucocorticoid-resistant leukemia cell model and found a long noncoding RNA, HOTAIRM1, was overexpressed in the resistant cells by transcriptional profiling, and was higher expressed in patients with poor prognosis.

[Blood Advances] To obtain insight into changes in translation induced by ribosomal protein S15 (RPS15) mutations in chronic lymphocytic leukemia (CLL) cells, the authors evaluated primary CLL cells from patients with wild-type or mutant RPS15 as well as MEC1 CLL cells transfected with mutant or wild-type RPS15.

[Blood Cancer Discovery] This Phase Ib trial evaluated ficlatuzumab, a first-in-class anti-HGF antibody, in combination with cytarabine in acute myeloid leukemia (AML) patients. Among 17 evaluable patients, the overall response rate was 53%, all complete remissions.

[Science] Researchers characterized the cellular and developmental context of preleukemic initiation and leukemic progression using gene editing in human disomic and trisomic fetal hematopoietic cells and xenotransplantation.

[Bone Marrow Transplantation] Scientists performed a landmark study comparing long-term outcomes in acute myeloid leukemia patients alive and disease-free two years after transplantation who received grafts from either cord blood transplantation or unrelated donors.

[Clinical Cancer Research] Scientists examined the effects of a rapamycin pretreatment of epithelial cell adhesion molecule (EpCAM) chimeric antigen receptor (CAR)-T cells and assessed the in vivo antitumor efficacy of rapamycin pretreated EpCAM CAR-T cells and CD33 CAR-T cells in leukemia xenograft mouse models.