The Long Noncoding RNA HOTAIRM1 Controlled by AML1 Enhances Glucocorticoid Resistance by Activating RHOA/ROCK1 Pathway through Suppressing ARHGAP18

Investigators established an acquired glucocorticoid-resistant leukemia cell model and found a long noncoding RNA, HOTAIRM1, was overexpressed in the resistant cells by transcriptional profiling, and was higher expressed in patients with poor prognosis.