RPS15 Mutations Rewire RNA Translation in Chronic Lymphocytic Leukemia

To obtain insight into changes in translation induced by ribosomal protein S15 (RPS15) mutations in chronic lymphocytic leukemia (CLL) cells, the authors evaluated primary CLL cells from patients with wild-type or mutant RPS15 as well as MEC1 CLL cells transfected with mutant or wild-type RPS15.