leukocytes

[Angiogenesis] Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning.

[Cell Reports Methods] The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.

[Laboratory Investigation] Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.

[Stem Cell Reviews and Reports] Scientists cultured adipose-derived MSCs from seven donors in PowerStem MSC1 media and StemMACS MSC Expansion Media and examined their growth and colony-forming ability, surface marker expression, differentiation, cell cycle and senescence, as well as genetic stability of two passages representing an early and late passage for therapeutic MSCs.

[Scientific Reports] Scientists investigated the impact of pretransplant desensitization with rituximab on anti-donor T cell responses in donor-specific anti-human leukocyte antigen antibody-positive transplant recipients.

[Cancer Cell] Investigators reported that a bifunctional fusion protein that simultaneously inhibited TGF-β and PD-L1, bintrafusp alfa, effectively synergized with radiotherapy, leading to superior survival in multiple therapy-resistant murine tumor models with poor immune infiltration.