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leukocytes

Human Oral Mucosa Cell Atlas Reveals a Stromal-Neutrophil Axis Regulating Tissue Immunity

[Cell] To aid in understanding tissue-specific pathophysiology, researchers compiled a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis.

Complement System in Alcohol-Associated Liver Disease

[Immunology Letters] In this review, scientists present a compendium of studies evaluating the role of complement in human and murine models of associated liver disease.

Serum Free Culture for the Expansion and Study of Type 2 Innate Lymphoid Cells

[Scientific Reports] Researchers demonstrated for the first time a methodology allowing mouse type 2 innate lymphoid cells to be cultured, and their numbers expanded in serum-free medium supplemented with Interleukins IL-33, IL-2, IL-7 and TSLP.

Identification of Presented SARS-CoV-2 HLA Class I and HLA Class II Peptides Using HLA-Peptidomics

[Cell Reports] Utilizing HLA-peptidomics researchers were able to identify SARS-CoV-2-derived peptides presented by highly prevalent HLA Class-I (HLA-I) molecules using infected cells as well as overexpression of SARS-CoV-2 genes.

Infectious and Lifestyle Modifiers of Immunity and Host Resilience

[Immunity] The authors explore the involvement of diverse mechanisms, including trained immunity, and their relevance for infections and cardiovascular disease, as these prevalent conditions are heavily influenced by immune cell abundance and phenotypic adaptions.

Surfactant Protein a Modulates the Activities of the JAK/STAT Pathway in Suppressing Th1 and Th17 Polarization in Murine OVA-Induced Allergic Asthma

[Laboratory Investigation] The authors conducted a study to investigate the effect and mechanisms of action of surfactant protein A in OVA-induced asthmatic mice.

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