leukocytes

[Journal of Experimental Medicine] Using single-cell transcriptomics and T cell receptor sequencing, scientists analyzed mononuclear cell populations in paired pleural fluid and peripheral blood of tuberculous pleural effusion patients.

[Clinical Science] Scientists investigated the potential effects of solid lipid nanoparticles containing dimethyl fumarate, administered by inhalation on the clinical signs, central nervous system inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis.

[Cancer Immunology Immunotherapy] Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.

[Molecular Therapy-Oncolytics] Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.

[Science Immunology] It is assumed that angiogenesis-induced suppression of adhesion molecules is a regulatory function to provide an embryo with immune privileged conditions and allow uninterrupted growth and development. It is becoming clear that similar conditions are used by tumors to evade the immune system and ensure progressive growth.

[Cellular and Molecular Life Sciences] Researchers investigated the molecular mechanisms that determined intercellular adhesion receptor (ICAM)-1 localization into apical membrane domains of polarized hepatic epithelial cells, and their effect on lymphocyte-hepatic epithelial cell interaction.