liver fibrosis

[Science Translational Medicine] Researchers identified that increased expression of the Notch ligand Jagged1 tracked with Notch activation and nonalcoholic fatty liver disease activity score in human liver biopsy specimens and mouse NASH models.

[Cell Death & Disease] Scientists showed that monocyte/macrophage CD11B mRNA levels were increased significantly in livers of biliary atresia patients and positively correlated with the progression of liver inflammation and fibrosis.

[Scientific Reports] Investigators showed that while ablation of ADAM17 resulted in decreased shedding of TNF RI, ADAM10 deficiency led to increased levels of soluble TNF RI in serum.

[Scientific Reports] Scientists established liver fibrosis models using multicellular tumor spheroids (MCTSs) composed of hepatocellular carcinoma (HCC) and stromal cells such as fibroblasts (WI38), hepatic stellate cells (LX2), and endothelial cells (HUVEC) seeded at constant ratios.

[Liver International] Investigators evaluated the hypothesis that myofibroblastic (activated) hepatic stellate cells and liver fibrosis could be safely reduced by inhibiting the cysteine/glutamate antiporter xCT.

[Nature Reviews Immunology] The authors review our current knowledge on the immunobiology and pathogenesis of Hepatitis B virus infection, focusing in particular on the role of CD8+ T cells and on several recent breakthroughs that challenge current dogmas.