lung carcinoma

[European Journal of Pharmacology] While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.

[Anti-Cancer Drugs] Subcutaneous A549 lung cancer and murine Lewis lung carcinoma (LLC) models were constructed, which were further intravenously injected with platinum-based drugs or concomitant administrated with anti-PD-1 antibody and or anti-NKG2D antibody.

[Cancer Gene Therapy] Researchers demonstrated that F-BAR and mu homology domains existed separately in human lung tissues and that one truncated form was not detected in patients with lung cancer.

[Cell Death & Disease] Investigators demonstrated that miR-4293 expression was markedly enhanced in lung carcinoma tissue and cells and miR-4293 promoted tumor cell proliferation and metastasis but suppressed apoptosis.

[Proceedings of the National Academy of Sciences of the United States of America] Leveraging the use of mass cytometry combined with multiplex major histocompatibility complex class I tetramer staining, researchers screened and identified tumor neoantigen–specific CD8+ T cells in the Lewis Lung carcinoma tumor model.

[Molecular Cancer Research] Investigators identified miR-324-5p as a critical epigenetic regulator of cancer stemness and demonstrated its role in mediating gain-of-function -mutant p53-driven stemness phenotype.