lymphocytes

[Science Immunology] Researchers showed that SOCS1 was a critical node integrating both IL-2 and IFN-γ signals to block multiple downstream signaling pathways abrogating CD4+ T helper 1 (TH1) cell response.

[Nature Biomedical Engineering] The authors showed that T cell-mediated cancer-cell killing was hampered for cortically soft cancer cells, which have plasma membranes enriched in cholesterol.

[Science Immunology] Investigators found that monophosphoryl lipid A (MPLA) self-assembled with saponins to form particles physically resembling immune-stimulatory complexes, which they termed saponin/MPLA nanoparticles.

[Cell Reports] Investigators used flow cytometry, T cell receptor sequencing, single-cell transcriptomics, and cytokine analysis to profile virus-specific CD8+ T cells recognizing the ubiquitous pathogens influenza and cytomegalovirus.

[Cell] The authors immunized rhesus macaques and assessed immune responses over one year in blood, upper and lower airways.

[Science Advances] The authors examined how during the course of B cell activation E2A and E2-2 gene expression was regulated.