lymphocytes

[Immunity] Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.

[Nature Communications] Using single-cell RNA sequencing of immune cells from renal clear cell carcinoma patients, investigators identified two distinct transcriptional fates for tumor-infiltrating Treg cells, Fate-1 and Fate-2.

[Journal of Immunology] The authors showed that direct fusion of CD40L to certain agonistic anti-CD40 Abs conferred superagonist properties, reducing the dose required for efficacy, notably greatly increasing total cytokine secretion by human dendritic cells.

[Nature Communications] The authors showed that the majority of people living with HIV with ART suppressed HIV viral load, mounted a detectable adaptive immune response to SARS-CoV-2.

[Scientific Reports] Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.

[Cell Reports] The authors demonstrated a trigger of thymic regeneration, centered on detecting the loss of dying thymocytes that were abundant during steady-state T cell development.