lymphocytes

[Cancer Discovery] The authors found that SHP2 inhibitor treatment depleted alveolar and M2-like macrophages, induced tumor-intrinsic CCL5/CXCL10 secretion and promoted B and T lymphocyte infiltration in Kras- and Egfr-mutant non-small cell lung cancer.

[Frontiers in Immunology] Using various clinically and physiologically relevant systems, researchers showed that a prominent feature of PD-1-expressing exhausted T cells was the development of cellular senescence features both in vivo and ex vivo.

[Nature Communications] Scientists developed and utilized a capture-based sequencing panel, which covered host hotspot genes and the full-length genome of human T-cell leukemia virus type-1, to investigate the clonal architecture of adult T-cell leukemia-lymphoma.

[Nature Reviews Cancer] Scientists discuss the interplay between the DNA damage response and anticancer immunity and highlight how this dynamic interaction contributes to shaping tumour immunogenicity.

[Cell Research] Investigators developed a next-generation IL-15 that is activated inside the tumor microenvironment.

[Cell Host & Microbe] AAVCOVID-1, an adeno-associated viral (AAV), spike gene-based vaccine candidate demonstrated potent immunogenicity in mouse and nonhuman primates following a single injection and conferred complete protection from SARS-CoV-2 challenge in macaques.