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Pulmonary Cell NewsUsing various clinically and physiologically relevant systems, researchers showed that a prominent feature of PD-1-expressing exhausted T cells was the development of cellular senescence features both in vivo and ex vivo.
[Frontiers in Immunology]
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Janelle, V., Neault, M., Lebel, M.-È., De Sousa, D. M., Boulet, S., Durrieu, L., Carli, C., Muzac, C., Lemieux, S., Labrecque, N., Melichar, H. J., Mallette, F. A., & Delisle, J.-S. (2021). p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells. Frontiers in Immunology, 0. https://doi.org/10.3389/fimmu.2021.698565 Cite
