An AAV-Based, Room-Temperature Stable, Single Dose COVID-19 Vaccine Provides Durable Immunogenicity and Protection in Non-Human Primates

By
Justin.choi
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AAVCOVID-1, an adeno-associated viral (AAV), spike gene-based vaccine candidate demonstrated potent immunogenicity in mouse and nonhuman primates following a single injection and conferred complete protection from SARS-CoV-2 challenge in macaques.
[Cell Host & Microbe]
Zabaleta, N., Dai, W., Bhatt, U., Hérate, C., Maisonnasse, P., Chichester, J. A., Sanmiguel, J., Estelien, R., Michalson, K. T., Diop, C., Maciorowski, D., Dereuddre-Bosquet, N., Cavarelli, M., Gallouët, A.-S., Naninck, T., Kahlaoui, N., Lemaitre, J., Qi, W., Hudspeth, E., … Vandenberghe, L. H. (2021). An AAV-based, room-temperature stable, single dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates. Cell Host & Microbe, 0(0). https://doi.org/10.1016/j.chom.2021.08.002 Cite
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