lymphocytes

[Advanced Healthcare Materials] A preprocessing strategy was developed to reprogram the immunosuppressive tumor microenvironment using a thermoresponsive hydrogel loaded with doxorubicin.

[Heliyon] Investigators discuss the possible use of natural killer (NK) cells cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

[Cancer Research] To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, the authors generated a penetrant double oncogene-driven autochthonous model of neuroblastoma.

[Blood] Researchers uncovered an immune-endocrine regulatory circuit that mediated cross-talk between peripheral B-cells and progenitors in the bone marrow, to balance B-lymphopoiesis in both human and mouse aging.

[Journal of Experimental Medicine] The authors discovered that selective recruitment and activation of systemic CD8+ T cells into DNA mismatch repair colorectal cancers strictly depend on overexpression of CCL5 and CXCL10 due to endogenous activation of cGAS/STING and type I IFN signaling by damaged DNA.