Peripheral B-Cells Repress B-Cell Regeneration in Aging through a TNFα/IGFBP-1/IGF1 Immune-Endocrine Axis

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Researchers uncovered an immune-endocrine regulatory circuit that mediated cross-talk between peripheral B-cells and progenitors in the bone marrow, to balance B-lymphopoiesis in both human and mouse aging.
[Blood]
Abstract