lymphocytes

[Nature Genetics] Researchers quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ solid tumor cell lines in multiplexed format and applied genome-scale CRISPR-based gene-editing screens in several solid tumor cell lines, to functionally interrogate which genes in tumor cells regulate the response to NK cells.

[Nature Reviews Immunology] The authors review CD8+ T cell differentiation to dysfunctional states during tumorigenesis.

[Communications Biology] Researchers showed that a combination immunotherapy platform utilizing low dose chemotherapy combined with oncolytic virotherapy increased tumor-infiltrating lymphocytes, in otherwise immune-bare tumors, allowing 60% of mice to achieve durable tumor regression when treated with immune checkpoint blockade.

[Immunological Investigations] To illustrate the role of Rank-RankL in Th17 differentiation, naive CD4+ T cells were differentiated into T helper 17 cells with or without RankL stimulation.

[Current Opinion in Immunology] Although IgE responses are normally constrained, recent studies suggest that specific conditions can induce the formation of IgE responses with enhanced affinity or longevity, effectively ‘breaking the rules’ of IgE regulation.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that peripheral circulating NK cells differentiated down two divergent pathways within the tumor microenvironment, resulting in different end states.