lymphocytes

[Genes & Diseases] With a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, investigators found that specific CD8+ T cell responses were identified in over 75% of COVID-19 convalescent patients

[Nature] The authors showed that the cytidine diphosphate–ethanolamine pathway co-ordinated the expression and localization of CXCR5 with the responses of T follicular helper (TFH) cells and humoral immunity.

[Reproductive Sciences] Using a tube formation assay between HTR8/SVneo cells and human umbilical vein endothelial cells, scientists found that Tim-3 pathway blockade inhibits tube formation and reversed by addition of recombinant IL-4 and/or IL-10.

[Nature Reviews Urology] CAR T cell therapy has the potential to be combined with other treatment modalities, such as androgen deprivation therapy, radiotherapy or chemotherapy, and could be applied as focal CAR T cell therapy for prostate cancer.

[Advanced Materials] T-cell-derived nanovesicles produced by the serial extrusion of cytotoxic T cells through membranes with micro-/nanosized pores that inhibit T-cell exhaustion and exhibit antitumoral activity maintained in the immunosuppressive tumor microenvironment were presented.

[Blood] To identify and interrogate malignant clones in matched skin and blood from leukemic MF and SS patients, we combine T cell receptor clonotyping, with quantification of gene expression and cell surface markers at the single cell level.