lymphocytes

[Science Translational Medicine] The authors presented a microbial-based immunotherapeutic treatment for selective delivery of an immunogenic tetanus toxoid protein into pancreatic ductal adenocarcinom tumor cells by attenuated Listeria monocytogenes.

[Nature Communications] By investigating the resistance mechanisms, scientists found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.

[Neurobiology of Disease] Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson's disease brain will provide targets for disease modification.

[International Immunology] The authors summarize the advances in our understanding of the ability of different types of TLRs and their downstream signaling pathways to activate anti-tumor immunity in T cells.

[Science Advances] Using a reverse translational approach, investigators showed a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism.

[BMC Cancer] Researchers observed tumor formation in NOD SCID mice after a single subcutaneous injection of human umbilical cord-MSCs and the effect of these cells on tumor growth in tumor-bearing mice.