CRISPR Activation Screen Identifies BCL-2 Proteins and B3GNT2 as Drivers of Cancer Resistance to T Cell-Mediated Cytotoxicity

By investigating the resistance mechanisms, scientists found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.