lymphocytes

[Scientific Reports] Investigators demonstrated that, in an in vitro setting, MAPC cells increase Treg frequencies by promoting Treg proliferation and CD4+ T cell differentiation into Tregs.

[Proceedings of the National Academy of Sciences of the United States of America] Using different preclinical models for liver metastasis, researchers found that tissue-resident type I innate lymphoid cells controlled metastatic seeding, whereas conventional NKs restrain outgrowth.

[Kite] Kite, a Gilead Company announced top-line results from the primary analysis of ZUMA-7, a randomized Phase III global, multicenter study showing superiority of Yescarta® compared to standard of care in second-line relapsed or refractory large B-cell lymphoma.

[Communications Biology] Scientists showed that viral infection attenuated the expression of genes related to lipid metabolism in murine CD4+ T cells, which in turn increased the expression of antiviral genes.

[Scientific Reports] Scientists demonstrated that YIV-906 plus anti-PD1 could eradicate all Hepa 1–6 tumors in all tumor bearing mice. YIV-906 was found to have multiple mechanisms of action to enhance adaptive and innate immunity.

[Oncogene] Scientists summarized recent findings on the heterogeneous subset composition of B cells in both human and mouse tumor models and their different impacts on disease progression.