lymphocytes

[Immunologic Research] In this current study, the authors discovered that epidermal growth factor receptor affected major histocompatibility complex class I mRNA and protein expression by human pancreatic cancer cell lines.

[Science Immunology] Investigators review transforming growth factor–β1 (TGF-β1) signaling in T regulatory cell (Treg) development and function and discuss knowledge gaps, future research, and the TGF-β1/Treg axis in the context of cancer immunotherapy and fibrosis.

[PLoS One] Researchers described a simple and effective protocol to study the cytotoxic activity of primary human NK cells toward the 3D tumor spheroids.

[Hepatology] The authors showed that vaccinating with simian adenovirus vector encoding conserved sequences across gt1-6 and gt-1a E2 protein with variable regions deleted sequentially in mice generated T cell and antibody responses comparable to either vaccine given alone.

[Science Immunology] Using a mouse model of chronic allergen exposure followed by an allergen-free rest period, scientists characterized a subpopulation of CD4+ T cells that secreted IL-9 as an obligate effector cytokine.

[Journal of Hematology & Oncology] Investigator established a target-redirected universal CAR-T cell therapeutic modality, in which exogenous antigens were loaded onto fusogenic nanoparticles to achieve in situ modification of cell membrane in solid tumors, providing targets for subsequent CAR-T cell therapy.