lymphocytes

[EMBO Molecular Medicine] Scientists demonstrated that ex vivo lentivirus-modified, rapamycin-conditioned CD4+ T cells could also act as next-generation cellular delivery vehicles—that is, “micropharmacies”—to disseminate corrective enzymes for multiple lysosomal storage disorders.

[Nature Communications] Investigators showed that higher intratumoral frequencies of γδ T cells, which have potential for HLA-unrestricted tumor reactivity, associated with enhanced hepatocellular carcinoma patient survival.

[Molecular Therapy Oncolytics] Scientists provide an updated review and future perspectives on features of the tumor microenvironment that represent barriers to CART cell therapy efficacy, including competition for metabolic fuels, physical barriers to infiltration, and immunosuppressive factors.

[Clinical Cancer Research] Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.

[Nature Immunology] Using a novel HLA-DRB1*15:01/S751 tetramer to track spike-specific CD4+ T cells, scientists showed that primary infection or vaccination induced robust S751-specific CXCR5− and cTFH cell memory responses.

[Immunogenetics] The authors investigated the effect of Myd88 silencing on dendritic cell function and immune response. CD34+ cells were isolated from the bone marrow of rhesus monkeys by the immunomagnetic bead method and then infected with an adenovirus expressing Myd88-specific short hairpin RNA.