Myd88 Knockdown with RNA Interference Induces In Vitro Immune Hyporesponsiveness in Dendritic Cells from Rhesus Monkeys

The authors investigated the effect of Myd88 silencing on dendritic cell function and immune response. CD34+ cells were isolated from the bone marrow of rhesus monkeys by the immunomagnetic bead method and then infected with an adenovirus expressing Myd88-specific short hairpin RNA.