A subcutaneous injectable acellular pancreatic extracellular matrix platform for localizing the bioengineered β cells while creating a pancreas‐like immunogenic microenvironment, in which the autoreactive T cells can interface with the β cells, was devised.
The authors describe the step wise generation and characterization of macrophages from iPSCs using a defined serum free method amenable to scale up to generate a large batch of pure end stage cryopreservable macrophages.
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Scientists investigated the downstream signaling pathways by which IgD activated T cells as well as the possible role of IgD in the T–B interaction.
[Acta Pharmacologica Sinica]
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Hu, X., Zhang, A., Pan, W., Xin, Q., Chen, J., Zhang, L., Chang, Y., Wu, Y., & Wei, W. (2021). An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis. Acta Pharmacologica Sinica, 1–14. https://doi.org/10.1038/s41401-021-00665-w Cite
CARs containing a CD28-TMD, but not a CD8-TMD, formed heterodimers with the endogenous CD28 in human T cells, as shown by co-immunoprecipitation and CAR-dependent proliferation of anti-CD28 stimulation.
[Frontiers in Immunology]
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Muller, Y. D., Nguyen, D. P., Ferreira, L. M. R., Ho, P., Raffin, C., Valencia, R. V. B., Congrave-Wilson, Z., Roth, T. L., Eyquem, J., Van Gool, F., Marson, A., Perez, L., Wells, J. A., Bluestone, J. A., & Tang, Q. (2021). The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.639818 Cite
Researchers observed significantly less human leukocyte antigen-G in plasma from immune thrombocytopenia patients positive for anti-platelet autoantibodies compared with autoantibodies-negative patients or healthy controls.
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Li, X., Sheng, Z., Sun, Y., Wang, Y., Xu, M., Zhang, Z., Li, H., Shao, L., Zhang, Y., Yu, J., Ma, C., Gao, C., Hou, M., Ni, H., Peng, J., Ma, J., & Feng, Q. (2021). Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia. Haematologica, 106(3), 770–781. https://doi.org/10.3324/haematol.2018.204040 Cite
In vivo and in vitro experiments showed that N-docosahexaenoylethanolamine: improved indicators of anxiety and long-term memory; inhibited the pro-inflammatory microglial cells activity; decreased the level of pro-inflammatory cytokines/ROS/NO/nitrites; increased CD206 and superoxide dismutase production.
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Ponomarenko, A. I., Tyrtyshnaia, A. A., Pislyagin, E. A., Dyuizen, I. V., Sultanov, R. M., & Manzhulo, I. V. (2021). N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Scientific Reports, 11(1), 756. https://doi.org/10.1038/s41598-020-80818-9 Cite
To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment.
[Clinical Cancer Research]
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Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L. K., Reilly, E., Rahma, O. E., Clancy, T. E., Wang, J., … Wolpin, B. M. (2020). Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3141 Cite
Researchers used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
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Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL | Science Immunology. (n.d.). Retrieved November 24, 2020, from https://immunology.sciencemag.org/content/5/53/eabe0347 Cite
Researchers showed that the number of CD19-specific CAR-T cells with a 4-1BB and CD28 co-stimulatory domain was much greater with stimulation by aAPCs than that with beads.
[Journal of Cellular and Molecular Medicine]
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Evaluation of piggyBac‐mediated anti‐CD19 CAR‐T cells after ex vivo expansion with aAPCs or magnetic beads - Yang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved November 23, 2020, from https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16118 Cite
Researchers evaluated individual dendritic cell activation profiles in the context of keratinocytes by R‐OOHs with regard to frequency, specificity and magnitude of upregulation.
[British Journal of Dermatology]
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Lichter, J., Sousa, M. S. e, Peter, N., Sahli, F., Vileno, B., Kuresepi, S., Gourlaouen, C., Giménez‐Arnau, E., & Blömeke, B. (n.d.). Skin sensitisation to fragrance hydroperoxides: interplay between dendritic cells, keratinocytes and free radicals. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19685 Cite
Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease]
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