Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes

A subcutaneous injectable acellular pancreatic extracellular matrix platform for localizing the bioengineered β cells while creating a pancreas‐like immunogenic microenvironment, in which the autoreactive T cells can interface with the β cells, was devised.
[Advanced Materials]
Associations of accumulated selected persistent organic pollutants in adipose tissue with insulin sensitivity and risk of incident type-2 diabetes. (2021). Environment International, 155, 106607. https://doi.org/10.1016/j.envint.2021.106607 Cite
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Generation of Cryopreserved Macrophages from Normal and Genetically Engineered Human Pluripotent Stem Cells for Disease Modelling

The authors describe the step wise generation and characterization of macrophages from iPSCs using a defined serum free method amenable to scale up to generate a large batch of pure end stage cryopreservable macrophages.
[PLOS ONE]
Munn, C., Burton, S., Dickerson, S., Bakshy, K., Strouse, A., & Rajesh, D. (2021). Generation of cryopreserved macrophages from normal and genetically engineered human pluripotent stem cells for disease modelling. PLOS ONE, 16(4), e0250107. https://doi.org/10.1371/journal.pone.0250107 Cite
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An IgD-FC-Ig Fusion Protein Restrains the Activation of T and B Cells by Inhibiting IgD-IgDR-Lck Signaling in Rheumatoid Arthritis

Scientists investigated the downstream signaling pathways by which IgD activated T cells as well as the possible role of IgD in the T–B interaction.
[Acta Pharmacologica Sinica]
Hu, X., Zhang, A., Pan, W., Xin, Q., Chen, J., Zhang, L., Chang, Y., Wu, Y., & Wei, W. (2021). An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis. Acta Pharmacologica Sinica, 1–14. https://doi.org/10.1038/s41401-021-00665-w Cite
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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization with CD28

CARs containing a CD28-TMD, but not a CD8-TMD, formed heterodimers with the endogenous CD28 in human T cells, as shown by co-immunoprecipitation and CAR-dependent proliferation of anti-CD28 stimulation.
[Frontiers in Immunology]
Muller, Y. D., Nguyen, D. P., Ferreira, L. M. R., Ho, P., Raffin, C., Valencia, R. V. B., Congrave-Wilson, Z., Roth, T. L., Eyquem, J., Van Gool, F., Marson, A., Perez, L., Wells, J. A., Bluestone, J. A., & Tang, Q. (2021). The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.639818 Cite
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Human Leukocyte Antigen-G Upregulates Immunoglobulin-Like Transcripts and Corrects Dysfunction of Immune Cells in Immune Thrombocytopenia

Researchers observed significantly less human leukocyte antigen-G in plasma from immune thrombocytopenia patients positive for anti-platelet autoantibodies compared with autoantibodies-negative patients or healthy controls.
[Haematologica]
Li, X., Sheng, Z., Sun, Y., Wang, Y., Xu, M., Zhang, Z., Li, H., Shao, L., Zhang, Y., Yu, J., Ma, C., Gao, C., Hou, M., Ni, H., Peng, J., Ma, J., & Feng, Q. (2021). Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia. Haematologica, 106(3), 770–781. https://doi.org/10.3324/haematol.2018.204040 Cite
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N-Docosahexaenoylethanolamine Reduces Neuroinflammation and Cognitive Impairment after Mild Traumatic Brain Injury in Rats

In vivo and in vitro experiments showed that N-docosahexaenoylethanolamine: improved indicators of anxiety and long-term memory; inhibited the pro-inflammatory microglial cells activity; decreased the level of pro-inflammatory cytokines/ROS/NO/nitrites; increased CD206 and superoxide dismutase production.
[Scientific Reports]
Ponomarenko, A. I., Tyrtyshnaia, A. A., Pislyagin, E. A., Dyuizen, I. V., Sultanov, R. M., & Manzhulo, I. V. (2021). N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Scientific Reports, 11(1), 756. https://doi.org/10.1038/s41598-020-80818-9 Cite
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Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment.
[Clinical Cancer Research]
Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L. K., Reilly, E., Rahma, O. E., Clancy, T. E., Wang, J., … Wolpin, B. M. (2020). Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3141 Cite
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Type I Interferons Drive the Maturation of Human DC3s with a Distinct Costimulatory Profile Characterized by High GITRL

Researchers used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
[Science Immunology]
Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL | Science Immunology. (n.d.). Retrieved November 24, 2020, from https://immunology.sciencemag.org/content/5/53/eabe0347 Cite
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Evaluation of piggyBac-Mediated Anti-CD19 CAR-T Cells after Ex Vivo Expansion with aAPCs or Magnetic Beads

Researchers showed that the number of CD19-specific CAR-T cells with a 4-1BB and CD28 co-stimulatory domain was much greater with stimulation by aAPCs than that with beads.
[Journal of Cellular and Molecular Medicine]
Evaluation of piggyBac‐mediated anti‐CD19 CAR‐T cells after ex vivo expansion with aAPCs or magnetic beads - Yang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved November 23, 2020, from https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16118 Cite
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Skin Sensitization to Fragrance Hydroperoxides: Interplay between Dendritic Cells, Keratinocytes and Free Radicals

Researchers evaluated individual dendritic cell activation profiles in the context of keratinocytes by R‐OOHs with regard to frequency, specificity and magnitude of upregulation.
[British Journal of Dermatology]
Lichter, J., Sousa, M. S. e, Peter, N., Sahli, F., Vileno, B., Kuresepi, S., Gourlaouen, C., Giménez‐Arnau, E., & Blömeke, B. (n.d.). Skin sensitisation to fragrance hydroperoxides: interplay between dendritic cells, keratinocytes and free radicals. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19685 Cite
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Immunomodulatory Activity of IR700-Labelled Affibody Targeting HER2

Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease]
Immunomodulatory activity of IR700-labelled affibody targeting HER2 | Cell Death & Disease. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41419-020-03077-6 Cite
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