Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

To generate spatially-resolved tumor and immune cell data at single cell resolution, investigators developed two quantitative multiplex immunofluorescence assays to interrogate myeloid cells and macrophages in the pancreatic ductal carcinoma tumor microenvironment.
[Clinical Cancer Research]
Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Costa, A. D., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L. K., Reilly, E., Rahma, O. E., Clancy, T. E., Wang, J., … Wolpin, B. M. (2020). Composition, spatial characteristics, and prognostic significance of myeloid cell infiltration in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3141 Cite
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Type I Interferons Drive the Maturation of Human DC3s with a Distinct Costimulatory Profile Characterized by High GITRL

Researchers used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
[Science Immunology]
Type I interferons drive the maturation of human DC3s with a distinct costimulatory profile characterized by high GITRL | Science Immunology. (n.d.). Retrieved November 24, 2020, from https://immunology.sciencemag.org/content/5/53/eabe0347 Cite
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Evaluation of piggyBac-Mediated Anti-CD19 CAR-T Cells after Ex Vivo Expansion with aAPCs or Magnetic Beads

Researchers showed that the number of CD19-specific CAR-T cells with a 4-1BB and CD28 co-stimulatory domain was much greater with stimulation by aAPCs than that with beads.
[Journal of Cellular and Molecular Medicine]
Evaluation of piggyBac‐mediated anti‐CD19 CAR‐T cells after ex vivo expansion with aAPCs or magnetic beads - Yang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved November 23, 2020, from https://onlinelibrary.wiley.com/doi/10.1111/jcmm.16118 Cite
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Skin Sensitization to Fragrance Hydroperoxides: Interplay between Dendritic Cells, Keratinocytes and Free Radicals

Researchers evaluated individual dendritic cell activation profiles in the context of keratinocytes by R‐OOHs with regard to frequency, specificity and magnitude of upregulation.
[British Journal of Dermatology]
Lichter, J., Sousa, M. S. e, Peter, N., Sahli, F., Vileno, B., Kuresepi, S., Gourlaouen, C., Giménez‐Arnau, E., & Blömeke, B. (n.d.). Skin sensitisation to fragrance hydroperoxides: interplay between dendritic cells, keratinocytes and free radicals. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19685 Cite
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Immunomodulatory Activity of IR700-Labelled Affibody Targeting HER2

Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease]
Immunomodulatory activity of IR700-labelled affibody targeting HER2 | Cell Death & Disease. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41419-020-03077-6 Cite
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NR4A Nuclear Receptors Restrain B Cell Responses to Antigen When Second Signals Are Absent or Limiting

Scientists showed that Nr4a1 and Nr4a3 played partially redundant roles to restrain B cell responses to antigen in the absence of co-stimulation and did so, in part, by repressing the expression of BATF and, consequently, MYC.
[Nature Immunology]
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Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-Activation Upstream of IL-22 Production

The authors showed delta-9-tetrahydrocannabinol (THC) attenuated colitis-associated colon cancer and colitis induced by anti-CD40. Working through cannabinoid receptor 2, THC increases CD103 expression on dendritic cells and macrophages and upregulates TGF-β1 to increase T regulatory cells
[iScience]
Becker, W., Alrafas, H. R., Wilson, K., Miranda, K., Culpepper, C., Chatzistamou, I., Cai, G., Nagarkatti, M., & Nagarkatti, P. S. (2020). Activation of cannabinoid receptor 2 prevents colitis-associated colon cancer through myeloid cell de-activation upstream of IL-22 production. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101504 Cite
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