“Double Hit” Strategy: Removal of Sialic Acid from the Dendritic Cell Surface and Loading with CD44⁺/CD24^–/Low Cell Lysate Inhibits Tumor Growth and Metastasis by Targeting Breast Cancer Stem Cells

The authors revealed that sialic acid removal and loading with CSC antigens induced significant molecular, morphological, and functional changes in dendritic cells (DCs) and that this new DC identity may be considered for future combined immunotherapy strategies against breast tumors.