lymphocytes

[BioMedX] A German independent research institute, BioMed X, announced the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ in collaboration with Merck KGaA, Darmstadt, Germany.

[Stem Cell Reviews and Reports] The authors describe the effects of various immune cells on intestinal stem cells (ISCs), as well as the mechanisms underlying these effects and also highlight the remarkable role of ISCs in intestinal pathogenesis.

[Modern Pathology] Ten patients had a history of B cell malignancies, one each of myeloid neoplasm, breast or prostate cancer, and four others had underlying immune disorders. Most patients died, mostly of disease, with a median overall survival of 12.7 months.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that proportional flux in the levels of aryl hydrocarbon receptor (AhR) nuclear translocator isoforms 1 and 3 modulated AhR signaling in terms of amplitude and expression of distinct gene programs.

[Science Advances] ECM proteins, collagen I, collagen III, and elastin, blocked natural killer (NK) cell cytotoxicity and promoted their chemokine/cytokine production. NK cell cytotoxicity against major histocompatibility complex class I (MHC-I)–deficient melanoma in the skin was markedly increased by blocking tumor collagen deposition.

[Thoracic Cancer] Investigators outline the basic structure and generation characteristic of chimeric antigen receptor-modified T (CAR-T) cells and summarize the common tumor-associated antigens in clinical trials of CAR-T cell therapy for lung cancer.