lymphocytes

[Journal of Hepatology] Scientists identified a proinflammatory hepatocyte subpopulation that developed primarily from periportal hepatocytes and to a lesser extent from pericentral hepatocytes and played key immunoregulatory roles in endotoxemia.

[Gut] The authors identified a group of clonotypes, characterized by semi-invariant T cell receptor alpha chains, to be significantly enriched in the blood of patients with Crohn’s disease and particularly expanded in the CD8+ T cell population.

[Cancer Immunology Research] Investigators showed that Tregs in tumor-bearing omenta predominantly had thymus-derived characteristics.

[Cancer Immunology Research] Scientists studied the consequences of pAg-stimulated γδ T cell interactions with Natural Killer cells and CD8+ T cells, major innate and adaptive effectors, respectively.

[Nature Reviews Immunology] The author discuss the increase in circulating Follicular helper T cells seen in autoimmune settings and explore potential explanations for this phenomenon.

[Science Immunology] The authors used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19.