lymphocytes

[Proceedings of the National Academy of Sciences of the United States of America] Scientists utilized continuous live-cell imaging in vitro to track the division speed and genealogical connections of all descendants derived from a single naive CD8+ T cell throughout up to ten divisions of activation-induced proliferation.

[Nature Cancer] Investigators discuss recent studies of bystander T cells in tumors, including experimental and computational approaches that enable their identification and functional analysis.

[Science Immunology] Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.

[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.

[International Journal of Biological Macromolecules] The authors discuss the role of TGF-β signaling in proliferation, metastasis and therapy response of prostate cancer cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-β such as non-coding RNAs are described.

[Nature Reviews Immunology] A pivotal event in the history of IL-2 research was solving the crystal structure of IL-2 bound to its tripartite receptor, which spurred the development of cell type-selective engineered IL-2 products.